Article

Regenerative cell therapy is a promising therapeutic strategy in neurology, most
notably to improve stroke recovery. Although tolerability and feasibility have
apparently been validated, many questions remain as to what is the best type of
cells to use, the best route and the post-stroke delay for administration. Two
main strategies have currently emerged: intravenous injection of mesenchymal stem
cells with systemic trophic support; and intracerebral grafting of neural stem
cells with brain repair effects at the lesion site. Multicenter clinical trials
have just begun and are starting to assess the efficacy of these treatments on
functional recovery. However, experimental studies also need to be conducted in
parallel to precisely identify the mechanisms of action regarding the
pathophysiology of brain plasticity, notably when stroke occurs with
comorbidities. Such studies should also evaluate the potential of cell grafting
combined with injectable biomaterials.
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Langue : ANGLAIS