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Rôle et régulation du récepteur D1 de la Dopamine dans le striatum : implications dans les dyskinésies de la maladie de Parkinson
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CORVOL JC; GIRAULT JA; HERVE D
REV NEUROL (Paris) , 2006, vol. 162, n° 6-7, p. 691-702 Doc n°: 126076 Localisation : Documentation IRR Descripteurs : AF5 - PARKINSON, AD33 - MOUVEMENTS ANORMAUX Url : http:// L-dopa treatment of Parkinson's disease is complicated in the long term by the appearance of dyskinesia. Hypersensitivity of D1 dopamine receptor has been suggested to play a role in these delayed adverse effects. Hypersensitivity of dopamine D1 receptor in Parkinson's disease can be accounted for by increased levels of Galphaolf, the stimulatory G protein which couples D1 receptor to adenylyl cyclase in the striatum. We here discuss the possible role of D1 receptor signal transduction in the genesis of L-dopa-induced dyskinesia in the light of Galphaolf regulation. Langue : FRANCAIS |
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